Season 2

Season 2 is the second season of B Positive premiered on CBS on October 14, 2021 and set to conclude on March 10, 2022.

Main

 * Thomas Middleditch as Drew Dunbar
 * Annaleigh Ashford as Gina Dabrowski
 * Kether Donohue as Gabby
 * Linda Lavin as Norma
 * David Anthony Higgins as Jerry Platt
 * Darryl Stephens as Gideon

Recurring

 * Izzy G as Maddie Dunbar
 * Terrence Terrell as Eli Russell
 * Hector Elizondo as Harry
 * Jane Seymour as Bette
 * Ben Vereen as Peter
 * Priscilla Lopez as Meredith
 * Jim Beaver as Spencer
 * Anna Maria Horsford as Althea Ludlum
 * Jason Kravits as Dr. Baskin

Guest

 * Sara Rue as Julia Dunbar

Trivia

 * On May 15, 2021, it was picked up for a second season.
 * Linda Lavin, David Anthony Higgins and Darryl Stephens are now billed for main role. They were previously billed as recurring role in the previous season.
 * This season is originally aired by October 7, however it was moved to one week on October 14, 2021.
 * After the season premiere Marco Pennette has departed only one season, then Warren Bell would replace Pennette as executive producer showrunner and writer.
 * This season is expected to replace 8:30PM timeslot for Ghosts.
 * Drew Dunbar’s Family Julia & Maddie plus Eli Russell  may often be absent or not appear  during in this season